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ORIGINAL ARTICLE
Year : 1998  |  Volume : 1  |  Issue : 1  |  Page : 35-40

Immunologic findings in meniere’s disease


ENT Department, Faculty of Medicine For Girls, Al-Azar University, Cairo, Egypt

Correspondence Address:
MD Naema M Ismail
21 Mohamed Yousef Saleem Street, Near El-Hejaz Square, El-Nozha, Heliopolis, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-8491.286854

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Twenty-four patients with Meniere’s disease were studied for the possibility of autoimmune aetiology. Ten normal adults of matching age and gender distributionserved as controls. Both groups were subjected to a battery of laboratory tests performed to evaluate the immunologic status namely ESR, C-reactive proteins (CRP), serum immunoglobulin levels, serum complement levels and serum autoantibody levels (Rheumatoid factor, anti DNA antibody and antinuclear antibody). Also a clinical search for associated autoimmune abnormalities in both groups was performed. There was a significant increase in ESR, CRP, IgG and antinuclear antibody (ANA) levels in the study group compared to the control group. Associated autoimmune abnormality was present in two cases (8.3 %) of the Meniere’s disease group and none of the control group. Steroid treatment for selected cases of the Meniere’s disease group produced 40% improvement. These data support the opinion of an autoimmune pathogenesis of some cases of Meniere’s disease.


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