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ORIGINAL ARTICLE
Year : 1998  |  Volume : 1  |  Issue : 1  |  Page : 41-47

Induction chemotherapy (Neoadjuvant) in the management of locally advanced untreated squamous cell carcinoma of the head and neck, a preliminary study


1 Radiotherapy and Oncology Unit, Al Hada Military Hospital, Taif, Saudi Arabia
2 Head and Neck Unit, Al Hada Military Hospital, Taif, Saudi Arabia
3 Anatomical and Clinical Pathology Unit, Al Hada Military Hospital, Taif, Saudi Arabia

Correspondence Address:
MD Mostafa Abdel Rahaman
Radiotherpay and Oncology Unit Al Hada Military Hospital, Taif
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-8491.286856

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This preliminary study was done at Al Hada Hospital Taif, Saudi Arabia, It was planned to assess the role of induction chemotherapy and radical radiotherapy in the treatment of locally advanced untreated squamous cell carcinoma of the head and neck. Eighteen patients were included in this study. Initially all patients received 2courses of chemotherapy using Cisplatinum and 5Fluorouracil infusions. Those with a response >50% were given, another one or two courses before radical irradiation.However, those with a response <50% were commenced on radical external irradiation. The overall response rate after 2 cycles of chemotherapy was 77.7%, all responded partially to treatment. However, a complete response rate of 28.5% was elicited after 3-4 cycles of treatment. Using this protocol larynx conservation was possible in the 3 cases included in this study. Treatment was well tolerated in the majority of cases. Furthermore, no treatment related mortalities were reported in this study. The disease free survival results at a specific time in the study were 66.7%, 63.6% and 33.3% at 1, 2 and 3 years respectivelyHowever when it was correlated with the study group as a whole the corresponding figures were as follows 66.7%,38%, & 11% respectively.


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