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ORIGINAL ARTICLE
Year : 2003  |  Volume : 5  |  Issue : 1  |  Page : 21-29

Prognostic value of MRI in nasopharyngeal carcinoma


1 Diagnostic Radiology Department, Faculty of Medicine, King Abdulaziz University; Dr. Erfan and Bagedo General Hospital,Jeddah, Saudi Arabia
2 Diagnostic Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; Dr. Erfan and Bagedo General Hospital,Jeddah, Saudi Arabia
3 Kasr Al-Aini Center of Clinical Oncology and Nuclear Meicine (NEMROCK), Faculty of Medicine, Cairo University, Cairo, Egypt; Dr. Erfan and Bagedo General Hospital, Jeddah, Saudi Arabia

Correspondence Address:
MD., FRCPC Sattam S Linjawi
P.O. Box 54403 Jcddah 21514
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-8491.289561

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Objective: The aim of this work was to evaluate the role of MRI in prediction of nasopharyngeal carcinoma (NPC) response to radiotherapy. Materials and Methods: Fifty-two NPC patients had MRI before and after radiotherapy to the local disease and the nodal involvement. The MRI assessed the size, site, signal intensity, enhancement pattern and extension of the regional disease in twenty-five anatomical sites. Radiotherapy was delivered using X-rays of 4-6 MV Linac. Results: Complete remission (CR) rates in the lateral, anterior, inferior, intracranial, orbital, skull base and paranasal sinuses extensions were 77% (177/229), 89%(23/28), 68%(13/19), 18%(5/28), 0%(0/5), 16%(28/17l) and 31%(9/29) respectively. The CR rate of the lateral, anterior, inferior extensions collcctivcly (Tl-2 lesions) was 77% (213/276) compared with 17.6% (42/238) for intracranial, orbital, skull base and paranasal sinuses extensions collectively (T3-4 lesions) (p<0.0000!). Among T2 lesions the CR rate was 89% (23/28) for nasal versus 68% (13/19) for oropharyngeal extension (p=0.04). Conclusion: The intracranial, orbital, skull base and paranasal sinuses extensions of NPC were associated with significantly lower rates of CR.


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