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CLINICAL RECORD
Year : 2003  |  Volume : 5  |  Issue : 1  |  Page : 38-41

Invasive aspergillosis of the cervical region and mediastinum - Case report and review of literature


Division of ENT, King Khalid National Guard Hospital, Jeddah, Saudi Arabia

Correspondence Address:
M.D., FRCS(C), FACS Essam Al-Zimaiti
Division of ENT, King Khalid National Guard Hospital P. O. Box 9515 Jeddah, 21423
Saudi Arabia
M.D., FRCS(C) Saad Al-Muhayawi
Division of ENT, King Khalid National Guard Hospital P. O. Box 9515 Jeddah, 21423
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-8491.289564

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Aspergillus species are ubiquitous in the environment worldwide. They can be found in the soil, water and vegetation. Non-invasive aspergillus lesions maydevelop in healthy paranasal sinuses or in pre-existing pulmonmary cavities. However, invasive aspergillosis (IA) is primarily an infection of severely immunocompromised patients and one of the most life-threatening conditions in this group of patients, with very high fatality rate. However, in immunocompetent persons, fulminant invasion of tissues is very rare. We report a case of a 30-year-old Saudi lady who developed invasive aspergillosis of the cervicalregion extending into the mediastinum and the vertebral foramina. This unusual infection was produced simultaneously by two species of Aspergillus i.e. A.fumigatus and A. niger. She was treated with a combination of amphotericin B i.v and itraconazole orally for 6 months. She responded very well to the combination therapy and made a remarkable recovery. Treatment options of this fatal infection are briefly reviewed and discussed.


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