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Year : 2009  |  Volume : 11  |  Issue : 1  |  Page : 21-24

Effectiveness of intranasal treatment with lysine acetylsalicylate in decreasing the relapse rate of nasal polyposis

Department of Otorhinolaryngology, Ain-Shams University, Cairo, Egypt

Correspondence Address:
Youssef Tamer
Department of Otorhinolaryngology, Ain-Shams University, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-8491.275321

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Objective: to examine the effect of long term topical (endonasal) treatment with Acetyl salicylic acid (ASA) on the recurrence rates of nasal polyps after endoscopic polypectomy in both aspirin sensitive and aspirin tolerant patients. Mehods: In our study we divided the patients into 2 groups: First group (study group): 36 patients with nasal polyps ( 21 men, 15 women ) aged 18-59 years were enrolled in the study. According to ENT indications, all patients underwent endoscopic removal of nasal polyps. About one month after surgery patients underwent intranasal treatment with increasing doses of lysine acetylsalicylate (LAS) corresponding to 450, 900 and 1800 microgram of LAS diluted in 2 ml normal saline and used as local spray in the nose once daily six times/week. Second group (control group): 40 patients with nasal polyps (26 men , 14 women, aged 18-58) who underwent endoscopic removal of nasal polyps and used saline nasal spray only postoperatively (placebo). Results: The difference between the 2 groups as regard the recurrence rate of the nasal polyps was statistically highly significant with (P<0.001, Fischer’s exact test). No statistical significant difference in the rates of recurrence was found between aspirin tolerant and aspirin sensitive patients (P>0.05). Conclusion:_In conclusion, the postoperative use of local ASA spray in the nose is safe, cost effective and significantly decreases the rate of recurrence of nasal polyps after surgery in both aspirin tolerant and aspirin sensitive patients.

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