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ORIGINAL ARTICLE
Year : 2010  |  Volume : 12  |  Issue : 1  |  Page : 14-17

Helicobacter pylori and its role in vocal folds minimal lesions


1 Otorhinolaryngology Head and Neck Surgery, Ain Shams University, KSA
2 Clinical Pathology Department, Ain Shams University, KSA

Correspondence Address:
MD M Tiba
Consultant & Chief of ORL Department Magrabi Hospital - Aseer
KSA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-8491.273967

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Background: Chronic laryngitis and/or vocal fold minimal lesions (VFML) are a common association with gastro esophageal reflux disease (GERD). Helicobacter Pylori (HP) is a Gram negative spiral organism accused of being a common cause of gastritis, gastro-esophageal reflux disease and peptic ulcer. HP has been recently isolated from tonsils, adenoids, sinus and middle ear mucosa in patients with chronic sinusitis or chronic middle ear effusion. Objective: To assess the presence of HP in (VFML). Methods: The study included fourteen patients with vocal folds minimal lesions (6 cases with vocal fold polyps and 4 cases with vocal fold nodules, and 4 cases with posteri-or granulomas; one of them associated with right VF nodule); all underwent Carbon 13 urea breath test (UBT), esophago-gastro-duodenoscopy (OGD) with gastric biopsy and direct laryngoscopy with microlaryngosurgery (MLS) to extract the VF lesions. Biopsies were subjected for two tests; detection of the 23S ribosomal RNA gene of HP by real-time polymerase chain reaction (RT-PCR) and Immunohistochemical reactions (IHC). Results: HP was detected by (RT-PCR) in ten of fourteen patients with VFML, HP was also detected by IHC in the same number of VFML and gastric mucosa specimens. Conclusion: HP is a common finding in cases of VFML; its eradication should be considered when dealing with a patient with VFML.


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