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ORGINAL ARTICLE
Year : 2013  |  Volume : 15  |  Issue : 2  |  Page : 23-26

Effect of use of mitomycin C in two different concentrations in laryngeal surgery


Department of Otolaryngology, Head and Neck Surgery, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
MD, FKSU Ahmed Y Al-Ammar
Department of Otolaryngology, Head and Neck Surgery, King Abdulaziz University Hospital, King Saud University, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-8491.290344

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Objective: To study the effect of topical mitomycin C 2 mg/ml in cases of laryngeal stenosis [subglottic stenosis and laryngeal web] and whether there is any difference in the outcome between the two different concentrations 2 mg/ml for 4 minutes and 0.4mg/ml for 4 minutes. By reviewing the literature there was no study found comparing the outcome of different concentrations of mitomycin C. Patients and Methods: This is a retrospective study of fifteen patients with laryngeal stenosis that were managed at King Abdulaziz University Hospital, King Saud University between June 2008 and February 2010. All patients underwent microlaryngoscopy and laser dilation followed by topical mitomycin C. The outcome of the single use of topical mitomycin C in two concentrations (2 mg/ ml and 0-4 me/ml) for 4 minutes was compared. Results: Twelve (80%) out of 15 with laryngeal stenosis improved after microlaiyngoscopy, laser dilation and the application of mitomycin C 2mg/mi, compared to 5 (42%) out of 12 patients who underwent the same procedures but with the application of mitomycin C 0.4mg/ml. Conclusion: According to our data, there was more benefit of the use of mitomycin C in higher concentration (2mg/ml for 4 minutes) and the observed difference was statistically significant p=0.025.


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