• Users Online: 371
  • Print this page
  • Email this page


 
 
Table of Contents
CASE REPORT
Year : 2022  |  Volume : 24  |  Issue : 2  |  Page : 82-84

Descending necrotizing mediastinitis of odontogenic origin - Management by minimal invasive approach


Department of Otorhinolaryngology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India

Date of Submission30-Jan-2022
Date of Decision26-Apr-2022
Date of Acceptance01-May-2022
Date of Web Publication10-Jun-2022

Correspondence Address:
Dr. Pratik Kumar
Department of Otorhinolaryngology, Pt. B. D. Sharma PGIMS, Rohtak - 124 001, Haryana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjoh.sjoh_7_22

Rights and Permissions
  Abstract 


Descending necrotizing mediastinitis is an uncommon, rapidly progressive pathology originating from odontogenic or cervical infections. It usually has a fulminant course, frequently leading to sepsis and mortality. A rare case of cervical necrotizing fasciitis and descending mediastinitis in a healthy young man, after an odontogenic infection with a successful outcome without aggressive surgical debridement, has been presented.

Keywords: Descending necrotizing mediastinitis, odontogenic, percutaneous drainage


How to cite this article:
Arora N, Goel A, Kumar P, Wadhawan A. Descending necrotizing mediastinitis of odontogenic origin - Management by minimal invasive approach. Saudi J Otorhinolaryngol Head Neck Surg 2022;24:82-4

How to cite this URL:
Arora N, Goel A, Kumar P, Wadhawan A. Descending necrotizing mediastinitis of odontogenic origin - Management by minimal invasive approach. Saudi J Otorhinolaryngol Head Neck Surg [serial online] 2022 [cited 2022 Dec 5];24:82-4. Available from: https://www.sjohns.org/text.asp?2022/24/2/82/347294




  Introduction Top


Acute mediastinitis usually develops after open cardiac surgery (incidence rate 1%–2.65%) or due to esophageal perforation resulting from iatrogenic intervention, trauma, foreign body ingestion, or neoplasm.[1] Pearse first described the term “descending necrotizing mediastinitis” for an infection arising from the head and neck, most commonly from an oropharyngeal or odontogenic focus, then extending along with the fascial spaces and descending down into the mediastinum.[2] Descending necrotizing mediastinitis has a high mortality rate between 40% and 50%.[3] A computed tomographic (CT) scan is an extremely useful tool for the diagnosis, surgical planning, and postoperative assessment of descending necrotizing mediastinitis. Early and sometimes multiple, radical debridement along with intravenous broad-spectrum antibiotic therapy has remained the cornerstone in the management of this condition.[4] However, with the advancement of medical science, less invasive surgical techniques may replace conventional aggressive debridement as the treatment of choice for descending necrotizing mediastinitis. An unusual case of descending necrotizing mediastinitis which is improved only by ultrasound-guided percutaneous catheter drainage is being presented.


  Case Report Top


A 29-year-old male [Figure 1] presented to the emergency department with a 5-day history of odynophagia, cervical swelling, persistent fever, chest discomfort, and shortness of breath. A few days before, this patient had experienced a left-sided lower molar ache, for which he had received 5 days of oral antibiotics. His neck movements were markedly restricted by pain; he also had trismus, dysphonia, and subcutaneous emphysema. After an otolaryngological examination, the patient was subjected to contrast-enhanced cervicothoracic CT to confirm the clinical diagnosis and evaluate the extent of infection. CT scan showed a collection of air and fluid in the left submandibular, parapharyngeal, pretracheal, and retrotracheal regions [Figure 2]. Diffuse enhancement of mediastinal fat with areas of air-fluid levels in the anterior mediastinal compartment was also noted along with left sided pleural effusion [Figure 3]. Laboratory investigations were within normal range, except for neutrophilia. The patient was admitted to the intensive care unit. Cervical abscess was drained percutaneously with a wide bore needle, and empyema was drained with the insertion of left-sided chest tube. Mycobacterium tuberculosis in the abscess fluid and pleural tap was ruled out with acid-fast staining, polymerase chain reaction, and culture. Tumor markers, electrocardiogram, and abdominal ultrasound showed no abnormal changes. Culture of cervical abscess fluid yielded Pseudomonas sp., and the patient was treated with intravenous piperacillin-tazobactam and amikacin. A repeat CT revealed a retrosternal collection treated with ultrasound-guided percutaneous catheter drainage under local anesthesia. The patient recovered subsequently. The chest tubes were replaced by empyema tubes without suction and were withdrawn gradually. Further radiological investigations showed complete resolution of the mediastinal and cervical air-fluid collections. After a total hospital stay of 1 month, the patient was discharged under stable conditions.
Figure 1: Patient with diffuse neck swelling

Click here to view
Figure 2: Coronal computed tomography neck showing air and fluid collection in parapharyngeal and perivascular space

Click here to view
Figure 3: Coronal computed tomography neck showing air and fluid collection in the anterior mediastinum with left-sided pleural effusion (marked with arrow)

Click here to view



  Discussion Top


Descending necrotizing mediastinitis has an incidence of 1.5%–3.6% in patients with deep neck infections.[5] Head and neck pathologies, commonly oropharyngeal or odontogenic infections, less frequently acute epiglottitis, cervical lymphadenitis, parotitis, thyroiditis, jugular intravenous drug abuse, and traumatic endotracheal intubation can lead to cervical necrotizing fasciitis and descending necrotizing mediastinitis.[6]

The presence of immunocompromising conditions predisposes for mediastinal extension of cervical necrotizing fasciitis. It is hypothesized that rapid downward spread of descending necrotizing mediastinitis is aided by the presence of negative thoracic pressure, poorly vascularized fascial spaces that lack cellular immune defenses, local tissue hypoxia resulting from multiple small vessel thromboses, and anaerobic bacterial enzymes that promote collagen breakdown and disruption of fascia.[7] Involvement of pretracheal and perivascular space can cause suppurative pericarditis and empyema. Prevertebral space infections can lead to posterior mediastinitis.

The most commonly isolated pathogens in descending necrotizing mediastinitis are a mixture of the aerobic (such as Streptococcus, Staphylococcus aureus, and Klebsiella pneumoniae) and anaerobic bacteria (Peptostreptococcus, Bacteroides fragilis, Prevotella, and Porphyromonas).[8] Empirical broad-spectrum antibiotic regimens covering these bacteria such as piperacillin-tazobactam and vancomycin and clindamycin with either third-generation cephalosporins or a quinolone are used.

In our case, Pseudomonas sp. was identified in the cervical fluid collection, which is quite uncommon. Even with the absence of other comorbidities, cervical necrotizing fasciitis rapidly progressed in our patient. Since prevertebral spaces were not involved, posterior mediastinitis was spared.

Various surgical options including cervical drainage alone to a combination of cervicotomy and transthoracic drainage using mediastinoscopy, thoracoscopy, thoracotomy, median sternotomy, or a clamshell incision have been described in the literature.[9],[10] In our case, ultrasound-guided percutaneous drainage was carried out, which was less invasive, reduced morbidity, and shortened the hospital stay. Percutaneous catheter drainage areas also have a lower risk of developing secondary infections and better pain control and may also prevent protein leakage from the wound.[11],[12]


  Conclusion Top


CT imaging is the most valuable modality for diagnosis and planning surgical management of descending necrotizing mediastinitis. In the last decade, due to a very high mortality rate, early and aggressive surgical debridement with open procedures has been practiced. We advocate that in this era, minimally invasive techniques can be explored to treat cervical necrotizing fasciitis and descending necrotizing mediastinitis, but more research is required to formulate the most suitable treatment protocol.

Informed consent

Written and informed consent was taken from the patient.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that his name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Diez C, Koch D, Kuss O, Silber RE, Friedrich I, Boergermann J. Risk factors for mediastinitis after cardiac surgery – A retrospective analysis of 1700 patients. J Cardiothorac Surg 2007;2:23.  Back to cited text no. 1
    
2.
Pearse HE Jr. Mediastinitis following cervical suppuration. Ann Surg 1938;108:588-611.  Back to cited text no. 2
    
3.
Marty-Ané CH, Berthet JP, Alric P, Pegis JD, Rouvière P, Mary H. Management of descending necrotizing mediastinitis: An aggressive treatment for an aggressive disease. Ann Thorac Surg 1999;68:212-7.  Back to cited text no. 3
    
4.
Wheatley MJ, Stirling MC, Kirsh MM, Gago O, Orringer MB. Descending necrotizing mediastinitis: Transcervical drainage is not enough. Ann Thorac Surg 1990;49:780-4.  Back to cited text no. 4
    
5.
Deu-Martín M, Saez-Barba M, López Sanz I, Alcaraz Peñarrocha R, Romero Vielva L, Solé Montserrat J. Mortality risk factors in descending necrotizing mediastinitis. Arch Bronconeumol 2010;46:182-7.  Back to cited text no. 5
    
6.
Moncada R, Warpeha R, Pickleman J, Spak M, Cardoso M, Berkow A, et al. Mediastinitis from odontogenic and deep cervical infection. Anatomic pathways of propagation. Chest 1978;73:497-500.  Back to cited text no. 6
    
7.
Makeieff M, Gresillon N, Berthet JP, Garrel R, Crampette L, Marty-Ane C, et al. Management of descending necrotizing mediastinitis. Laryngoscope 2004;114:772-5.  Back to cited text no. 7
    
8.
Brook I, Frazier EH. Microbiology of mediastinitis. Arch Intern Med 1996;156:333-6.  Back to cited text no. 8
    
9.
Endo S, Murayama F, Hasegawa T, Yamamoto S, Yamaguchi T, Sohara Y, et al. Guideline of surgical management based on diffusion of descending necrotizing mediastinitis. Jpn J Thorac Cardiovasc Surg 1999;47:14-9.  Back to cited text no. 9
    
10.
Chen KC, Chen JS, Kuo SW, Huang PM, Hsu HH, Lee JM, et al. Descending necrotizing mediastinitis: A 10-year surgical experience in a single institution. J Thorac Cardiovasc Surg 2008;136:191-8.  Back to cited text no. 10
    
11.
Sumi Y, Ogura H, Nakamori Y, Ukai I, Tasaki O, Kuwagata Y, et al. Nonoperative catheter management for cervical necrotizing fasciitis with and without descending necrotizing mediastinitis. Arch Otolaryngol Head Neck Surg 2008;134:750-6.  Back to cited text no. 11
    
12.
Nakamori Y, Fujimi S, Ogura H, Kuwagata Y, Tanaka H, Shimazu T, et al. Conventional open surgery versus percutaneous catheter drainage in the treatment of cervical necrotizing fasciitis and descending necrotizing mediastinitis. AJR Am J Roentgenol 2004;182:1443-9.  Back to cited text no. 12
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Introduction
Case Report
Discussion
Conclusion
References
Article Figures

 Article Access Statistics
    Viewed408    
    Printed30    
    Emailed0    
    PDF Downloaded39    
    Comments [Add]    

Recommend this journal