Saudi Journal of Otorhinolaryngology Head and Neck Surgery

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 24  |  Issue : 2  |  Page : 73--77

Changes in the histological characteristics of patients from a Southern Saudi Population with chronic rhinosinusitis with nasal polyps over time


Nasir A Magboul1, Abdelaziz Qobty2, Ali Alzarei1, Areej Rajah3, Meshary Alshahrani3, Zubaidah Alahmari3 
1 Department of ORL-HNS, Asir Central Hospital, Abha, Saudi Arabia
2 Department of ORL-HNS, King Khalid University, Abha, Saudi Arabia
3 Department of General Surgery, King Khalid University, Abha, Saudi Arabia

Correspondence Address:
Dr. Nasir A Magboul
Department of ORL-HNS, Asir Central Hospital, Al-Rabwah Street, Abha 62312
Saudi Arabia

Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most common type of inflammation of the mucosa of the sinonasal cavity. Approximately 65%–90% of CRSwNP cases exhibit eosinophilic inflammation. Patients with CRSwNP respond to corticosteroids but tend to have more severe diseases with higher recurrence rates. We aimed to determine the histopathological types of CRSwNP in patients who underwent surgery at Asir Central Hospital in Asir Region, Saudi Arabia, and compared patients admitted from 2013 to 2016 and 2018 to 2020 to identify changes in their histological patterns. Materials and Methods: We retrospectively examined medical records of patients who underwent surgery to remove nasal polyps during two different time periods (2013–2016 and 2018–2020). A pre-structured data collection sheet was used to extract data from medical records to ensure consistency. A histological review of nasal polyp tissue was collected during the surgery, immediately fixed in 10% formalin, and sent for histopathology. All specimens were processed in the same pathologic laboratory using the same histopathologic techniques. The average number of eosinophils, neutrophils, lymphocytes and plasma cells per high-power field (HPF) for each sample was recorded. Tissue eosinophil histopathologically defined when tissue eosinophil was >10/HPF. Results: Among the patients with CRSwNP admitted for surgical intervention, 162 and 92 patients were admitted from 2013 to 2016 (Group A) and 2018 to 2020 (Group B), respectively. Neutrophilic polyps were present in 30.2% of Group A patients compared to 27.2% of Group B patients. There were significantly more eosinophilic polyps diagnosed in Group B than in Group A (51.9% vs. 72.8%, respectively; P = 0.001). Significantly more polyps were benign in Group B than in Group A (97.8% vs. 71.6%, respectively; P < 0.001). Conclusions: There was an increase over time in eosinophilic nasal polyps among cases of CRSwNP in the Asir region. The frequency of neutrophilic polyps decreased over 7 years.


How to cite this article:
Magboul NA, Qobty A, Alzarei A, Rajah A, Alshahrani M, Alahmari Z. Changes in the histological characteristics of patients from a Southern Saudi Population with chronic rhinosinusitis with nasal polyps over time.Saudi J Otorhinolaryngol Head Neck Surg 2022;24:73-77


How to cite this URL:
Magboul NA, Qobty A, Alzarei A, Rajah A, Alshahrani M, Alahmari Z. Changes in the histological characteristics of patients from a Southern Saudi Population with chronic rhinosinusitis with nasal polyps over time. Saudi J Otorhinolaryngol Head Neck Surg [serial online] 2022 [cited 2022 Oct 4 ];24:73-77
Available from: https://www.sjohns.org/article.asp?issn=1319-8491;year=2022;volume=24;issue=2;spage=73;epage=77;aulast=Magboul;type=0